In this episode of the EuCornea IME video interview series on ocular surface disease (OSD), Profs. Mario Nubile and Sotiria Palioura uncover one of OSD’s most overlooked culprits – Demodex blepharitis. They discuss why this chronic, often underdiagnosed condition is so common, how to identify it, and how to select the most effective treatments, from established options to emerging approaches. The discussion highlights how systematic screening, patient education, and new in-office and at-home treatments can transform management and improve patient outcomes.